Development of a Murine Isogenic Graft Model of Endometriosis: Monitoring by dynamic contrast-enhanced MRI
Linnik I, Williams S, De Giorgio-Miller A, Murphy P, Buckley D
University of Manchester
The purpose of our study was to develop non-invasive method of studying endometriosis in a pre-clinical model. We used dynamic contrast-enhanced MRI (DCE-MRI) in a mouse isogenic graft model of endometriosis. Each animal was imaged on days 3, 7 and 10 after tissue implantation. Estimates of baseline T1, Ktrans, ve (interstitial volume) and kep (exchange rate) were obtained for each lesion and time point. No consistent change was observed in any parameter over the time frame studied.