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Abstract #2489

Dependency of Oxygen Extraction Calculations from a Static Dephasing Model on Capillary-Radius and Volume Fraction

Bongers A, Schroeder H, Schad L
mediri GmbH

Recent approaches try to map oxygen extraction fraction (OEF) in vivo by measuring average susceptibility difference maps from signal decay measurements with gradient-echo/spin-echo-sequences. These methods utilize a static spin dephasing model to calculate blood volume fraction (l), reversible relaxation rate (R2) and OEF. An important prerequisite for the applicability of this technique for OEF mapping is that the calculated susceptibility values are independent of capillary radius and volume fraction of the inclusions. In this work, a phantom study was performed to test the dependency of the measured susceptibility differences on l and capillary diameter.