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Abstract #2505

Effect of Multi-Component T1 and T2 Relaxation on Derived Single-Component DESPOT2 T2 Values

Deoni S
Institute of Psychiatry, King's College

Here we investigate the effect of multiple-component T1 and T2 relaxation on single-component T2 values derived using the rapid DESPOT2 (Driven Equilibrium Single Pulse Observation of T2) T2 mapping method. Further, we compare these values with those calculated using convention the spin-echo approach. An increased sensitivity of DESPOT2 to fast T2 components is demonstrated, even when these components have small volume fractions. This sensitivity may make DESPOT2 advantageous in imaging applications interested in fast T2 components, such as investigations of myelin in multiple sclerosis or during brain maturation.