MRI Phantoms with Independently-Controllable Biexponential-T2 Decays
Horch R, Does M
In this work, chemical formulations are presented for biexponential-T2 MRI phantoms at different field strengths. These phantoms are based on aqueous solutions of urea, in which the water relaxation pool can be controlled by inner-sphere contrast agents while the urea relaxation pool remains virtually unaffected. Outer-sphere contrast agents, which affect both water and urea relaxation pools, can then be used concomitantly to enable a wide, continuous range of phantom T2 combinations. Unlike previous biexponential phantoms, the phantoms presented here have negligible constraints on pool size ratios and shelf-life.