STUDY OF PILOCARPINE MODEL OF EPILEPTIC RATS AT 7 TESLA BY MAGNETIC RESONANCE SPECTROSCOPY
Cudalbu C, Cavassila S, Montavont A, Ryvlin P, Briguet A, Graveron-Demilly D
Universit Claude Bernard Lyon1, ESCPE
The brain of the pilocarpine rat is a well-studied model of temporal lobe epilepsy that reproduces most of the clinical and neuropathologic features of human temporal lobe epilepsy. The purpose of our study was to analyze by MRS the hippocampus region, 24 hours after the onset of Status Epilepticus. Short echo-time in vivo signals of brains of epileptic and healthy rats were acquired at 7Tesla and quantitated using QUEST. We detected a significant increase of the lactate concentration in the hippocampus of epileptic rat brains. Our concentration estimates obtained from the healthy rats are in good agreement with the published values.