Abstract #2700

Griebe M, Gnther M, Kern R, Sallustio F, Hennerici M, Szabo K, Gass A

We compared Arterial Spin Labelling (ASL) based dynamic angiography information blood flow velocity measurements in normal controls and patients with internal carotid artery (ICA) stenoses to transcranial Doppler (TCD). 18 middle cerebral arteries (MCAs) of 9 normal controls and 6 MCAs of 3 patients with unilateral ACI stenosis were examined. For the DynAngio sequence, 36 phases of inflow with a temporal resolution of 36ms and an in-plane resolution of 0.52mm were acquired on a clinical 1.5T scanner. Blood flow velocity was calculated from the covered distance of the vessel signal and the difference of the inflow time between the phases. These were compared to the mean blood flow velocities as detected by TCD. In all subjects, the DynAngio technique showed the inflow of the labelled blood bolus with good quality. TCD measures and DynAngio calculated MCA velocities correlated closely for both controls and ICA patients (r=0.89, p<0.0001). The DynAngio technique is useful in assessing MCA haemodynamics, providin