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Abstract #2722

Correlations between Diffusion Tensor Indices and Intravoxel Tissue Volume Fractions in Human Brain

Yang Y, Gu H, Stein E, Zhan W
National Institute on Drug Abuse, NIH

The intravoxel tissue volume fractions of white matter (WM), gray matter (GM) and cerebral-spinal fluid (CSF) are measured in the human brain by an inversion-recovery (IR) procedure. The voxel-wise fraction anisotropy (FA) and mean diffusivity (MD) are obtained by a diffusion tensor imaging (DTI) technique. Strong correlations are detected between the diffusion tensor indices and the intravoxel tissues fractions. Regression analysis was performed to establish the statistical relationships. The FA and MD maps can be decomposed according to the WM and GM fractions, respectively, and this decomposition provides tissue-specific DTI maps of the brain.