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Abstract #2728

Resolve Fiber Orientation Ambiguity Using HARD Imaging

Hong X, Anderson A, Ding Z
Vanderbilt University

Conventional Diffusion Tensor Imaging (DTI) cannot distinguish between fiber crossing, joining, kissing or bending in a voxel. Here we show that this ambiguity can be resolved with High Angular Resolution Diffusion (HARD) measurements and a simple model of partial volume averaging Fiber ORientation Estimated using Continuous Axially Symmetric Tensors (FORECAST). It is demonstrated both by numerical simulation and in vivo measurements. The technique may be useful for fiber tracking, and fiber bundles segmentation.