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Abstract #2740

Validation of multi-fibre probabilistic tractography of corticothalamic projections in the Gttingen minipig brain

Dyrby T, Alexander D, Vejby L, Parker G, Lind N, Paulson O, Jelsing J
Copenhagen University Hospital

Diffusion MRI probabilistic tractography enables in vivo tracking of axonal fibres in the brain and will be pivotal in studying brain connectivity in the pathological and healthy human brain. In the present study tractography was compared with real fibre tracts visualized using manganese as an anterogradely transported paramagnetic tracer. We demonstrate that it is possible to trace corticothalamic fibres using a high resolution in situ diffusion weighted dataset optimised for the detection of crossing fibres.