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Abstract #2924

Quantitative Assessment of Tumor Microstructure in Canine Brain Using High Resolution DTI Microimaging

Wang P, Robertson J, Zhu J, Rossmeisl, Jr. J, Shaw E, Robbins M
Wake Forest University School of Medicine

The purpose of this work was to demonstrate the potential of acquiring high resolution DTI images of fixed canine brains for studying spontaneously-developed brain tumor models. An accurate and yet quantitative imaging method was developed to map white matter microstructure in fixed canine brain with tumors. Using this procedure, extremely high resolution microstructural images were obtained. This leads a very accurate method to study microanantomical changes involving with tissue damage and integrity for animal models.