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Abstract #3115

Subacute changes in T2 signal evolution: Time-Series Modeling of Degenerative and Restorative Processes in MS

Guttmann C, Meier D
Brigham & Women's Hospital, Harvard Medical School

A pathophysiologically motivated two-process model was applied to frequent MRI of new multiple sclerosis (MS) lesions to study the intensity dynamics of new lesion formation in terms of inflammation and degeneration versus resorbtion and repair. Duration measurements were obtained from the model on a per-pixel basis and compared to the duration of contrast-enhancing activity. T2-weighted MRI appears sensitive toward non-inflammatory, subacute lesion evolution in MS.