Environmental Lead Exposure Alters Brain Volume: Results of a VBM Analysis
Cecil K, Adler C, Jarvis K, Elangovan I, Dietrich K, Lanphear B
Cincinnati Children's Hospital Medical Center
VBM analyses of high-resolution MR images offers novel information about the regions altered by childhood lead exposure. Subjects (N=159) exposed to significant levels of lead during childhood demonstrate reductions in total brain volume with regional gray and white matter deficits that correlate with mean childhood blood lead levels. In particular, frontal lobe gray and white matter reductions may explain deficits in cognitive and behavioral outcomes clinically observed in populations with significant lead exposure.