Oral creatine supplementation depresses ATP in healthy human brain
Pan J, Takahashi K
Albert Einstein College of Medicine
Oral creatine supplementation is frequently used to improve muscle function and has been increasingly used to improve neurological function. We used high resolution 31P spectroscopic imaging in healthy control volunteers (n=7) to assess the changes in energetics with 7 days of creatine supplementation at 20g/day. Image guided single voxel reconstruction was used to position the selected regions for optimum consistency. PCr/ATP ratios increased significantly in the thalamus and hippocampus while it was not significantly different in neortical regions. Quantification of the data showed that the ratio increase is primarily due to a decline in ATP.