Role of In-Vitro Proton NMR Spectroscopy in Inflammatory Bowel Disorders
Balasubramanian K, Sharma U, Kumar S, Makharia G, Jagannathan N
All India Institute of Medical Sciences
This study is aimed at identifying the two types of IBD- Ulcerative colitis (UC) and Crohns disease (CD) and differentiating it from ITB and normal using 1H NMR spectroscopy. 21 metabolites were assigned and the concentrations of 10 metabolites were determined. Significant decrease in lactate (Lac), glutamate+glutamine (Glu+Gln), myo-inositol (mI) and glycerophosphorylcholine (GPC) were observed in UC patients compared to controls. CD patients showed a decrease in Lac and Glu+Gln while those with tuberculosis (TB) showed a decrease in Lac, Glu+Gln and mI compared to controls. TB patients showed a decrease in Lac and Ace compared to UC and a decrease in Lac, Ace and mI compared to CD.