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Abstract #3260

Default mode functional connectivity altered by sevoflurane anesthesia

Peltier S, Hamann S, Kerssens C, Hu X, Byas-Smith M, Sebel P
Emory University/Georgia Tech

This study investigated how sevoflurane anesthesia affects functional connectivity associated with the posterior cingulate ( the default mode network). Resting-state MR scans were acquired under different levels of anesthesia (0, 2%, 1% sevoflurane). Across all subjects, the number of voxels covarying with the posterior cingulate was significantly decreased going from the awake state to deep anesthesia, and was subsequently increased going from deep to light anesthesia.