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Abstract #3263

The Minimum Detectable Change in fMRI Measurements of Brain Activity Across Imaging Sessions

Goodyear B, Douglas E
University of Calgary

To use fMRI to track post-stroke recovery and assess treatment, there is a need to obtain precise and reproducible fMRI measurements of brain function from individual stroke patients. Modest reproducibility of fMRI has been demonstrated, with the laterality index (LI, defined as contralateral minus ipsilateral divided by contralatreral plus ipsilateral activation) showing better reproducibility. In this study we determine the minimum detectable change in fMRI measurements of brain activity across imaging sessions. As a result, this will determine the usefulness of fMRI for clinical evaluations of the progression of functional recovery and reorganization following stroke in individual patients.