Mapping Pharmacological-Evoked fMRI Data Using Independent Component Analysis-Derived Pharmacodynamic Modeling
Wang P, Zhu J
Wake Forest University School of Medicine
Because the exact temporal model of BOLD changes associated with amphetamine action is difficulty to specify, the hypothesis-driven analysis method is not as exact as in other fMRI applications. We present a scheme that adds the ICA time course into the SPM design matrix (as the priori regressor), the results denoted this scheme can improve the SPM performance. Our further work will include establishing more accurate pharmacokinetic model based on ICA, and the combinations with SPM.