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Abstract #3273

Graded fMRI Response in Rat Rectal Distention Model

Shaker R, Pawela C, Kounev V, Hyde J
Medical College of Wisconsin

Functional disorders are the most common disease diagnosed by Gastroenterologists. The mechanisms behind these diseases are poorly understood but are believed to involve a disturbance in the interaction between the enteric nervous system, central nervous system, and the autonomic nervous system. The goal of this study was to develop a working fMRI protocol for an animal model of these disorders using rectal distention. A graded neurosensory response was observed for varying levels of balloon inflation.