A Filtered Subtraction Approach for the Reduction of Physiological Noise in Perfusion Based fMRI
Behzadi Y, Restom K, Perthen J, Liu T
University of California, San Diego
A previous study has shown that an image based retrospective method (RETROICOR) for the reduction of physiological noise could be modified to increase the sensitivity of ASL studies. The previously proposed method divided the tag and control images into two independent time series. Here we introduce an improved method that removes physiological noise from a perfusion time series formed from the filtered subtraction of the tag and control images. The proposed method improves the sensitivity to functional activation by a factor of four as compared to the previous method.