Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease using Continuous Arterial Spin Labeling on 3T-MR: Correlative Study with CO2 PET Examination.
Kabasawa H, Tsuchida T, Yonekura Y, Kimura H, Itoh H
GE Medical Systems
Multi-slice continuous arterial spin labeling (CASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral blood flow. However, it has not been investigated whether the hemodynamic changes that accompany cerebrovascular disease affect the utility of CASL in the assessment of CBF. The goal of the current study was to propose a two-compartment model for the quantification of CBF and arterial transit time and to compare CASL-CBF and CO2 PET-CBF in the assessment of regional cerebral blood flow in patients with chronic occlusive cerebrovascular disease.