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Abstract #3428

Accurate perfusion quantification using pulsed arterial spin labeling: Choosing appropriate sequence parameters

Restom K, Behzadi Y, Liu T, Lu K, Perthen J

Pulsed ASL techniques can provide quantitative measurements of resting and functional CBF using the QUIPSS II modification. However, accurate quantification of CBF requires that the scan parameters fulfill various conditions. In this study, we show that optimal pulsed ASL scan parameters show a strong dependence on experimental conditions (e.g. tag angle, brain region) and must therefore be tailored to specific study conditions rather than employing a universal approach or adopting literature values. Data from the visual cortex and hippocampus are presented to illustrate the impact of tag angle and brain region and to demonstrate how appropriate parameters can be chosen.