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Abstract #3438

Real Time Physiologic Monitoring of Intra Arterial rtPA Therapy in a Canine Model of Acute Embolic Stroke

Shin W, Rohany M, Harris K, Cashen T, Shaibani A, Carroll T
Northwestern University

The increasingly important role of Magnetic Resonance (MR) perfusion and diffusion imaging in understanding the pathophysiology of stroke caused increasing attention to combined MR-IR suites as a future management standard in acute stroke. In this study we demonstrate a MR compatible canine model for real time physiologic monitoring of IA rtPA thrombolytic therapy by measuring Apparent Diffusion Coefficient (ADC) values and quantitative cerebral blood flow (qCBF) values in infarcted regions during the IA rtPA injection.