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Abstract #3456

Relationships between Brain Water Content and Diffusion Tensor Imaging Parameters (Apparent Diffusion Coefficient, Fractional Anisotropy) in Multiple Sclerosis

Sijens P, Irwan R, Oudkerk M, Potze J

Fifteen multiple sclerosis patients were examined by diffusion tensor imaging (DTI) to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in a superventricular volume of interest of 882 cm3 containing gray matter (GM) and white matter (WM) tissue. PRESS 2D-CSI of the same volume was performed without water suppression to map water content. Water content was increased in patients compared with controls, FA decreased and ADC increased. The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests potential for therapy monitoring in normal appearing brain tissue.