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Abstract #3458

Neurodevelopmental studies in C57B/L6 mice assessed by in vivo DTI

Chahboune H, Stewart W, Ment L, Rothman D, Hyder F
Yale University

In vivo DTI for mouse brain studies is the ultimate goal of neurodevelopmental studies because various mutants or transgenic models are used to mimic several key neurological disorders which manifest through development. Here we assess the feasibility of in vivo DTI (at >9.4T) with high angular resolution and quantify the overall growth and maturation of microstructures in normal C57B/L6 mouse brain from P15 to P45. The most noticeable changes in DTI parameters were found in the corpus callosum. However other areas which were subject to maturation in normal brain development were also implicated from our results.