Age-related alterations of cerebral white matter: Analysis of normalized diffusion tensor images of healthy subjects grouped in narrow age ranges
Tha K, Terae S, Kudo K, Soma H, Yamamoto T, Yoshida Y, Yabe I, Sasaki H, Miyasaka K
Hokkaido University Graduate School of Medicine
Information about age-related effects on fractional anisotropy (FA) of cerebral white matter of subjects grouped in narrower age ranges is limited. This study evaluated age-related changes of cerebral white matter, using normalized FA images of 132 healthy subjects, aged 22-67 years. Both region-of-interest (ROI)-based and voxel-based morphometry (VBM) analysis were performed. FA of cerebral white matter declined with age. Earliest decline in FA was noted in frontal white matter. Study on normalized FA images of subjects grouped in narrower age ranges provided age- and region-specific alterations of cerebral white matter.