Fat Suppression Strategies for Off-Resonance (IRON) Imaging of Magnetically-Labeled Stem Cells High in Iron with 0% Fat
Barnett B, Kraitchman D, Bulte J, Stuber M, Shah S, Weiss R, Gilson W
Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine
IRON imaging is a method that enables the signal-enhanced visualization of superparamagnetic particles. However, since IRON method intrinsically highlights all off-resonant protons, the presence of fat leads to ambiguous image information. Based on theoretical considerations, we have developed different approaches for fat suppressed IRON imaging. The effectiveness of these fat suppression methods has then been tested in-vitro, and a fat suppressed IRON imaging method with maximized signal-to-noise ratio was identified.