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Abstract #3514

Magnetic Resonance Fe3O4-NH3+ Nanoparticles Coated with Anti-Epidermal Growth Factor Receptor Antibody for in vitro probing on Non-Small Cell Lung Cancer

Chen J, Yuan A, Lin W, Su C
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University

Magnetic nanoparticles play a significant role in MR study because of its superparamagnetic characteristic. In the previous study, the aqueous Fe3O4-NH3+ nanoparticles show excellent negative contrast in MR images for in vitro and in vivo experiments due to reducing proton relaxation times of T1 and T2, and also been convinced its biocompatibility, hemocompatibility, and low cytotoxicity at in vitro tests. Magnetic nanoparticles MR probe has already been a sharp weapon for tumor detection. In this study, we choose non-small cell lung cancer as our probing target. EGFR in NSCLC is overexpression and correlated with a high metastatic rate, poor tumor differentiation, and a high rate of tumor growth.We use Fe3O4-NH3+ nanoparticles coated with antibodies to target the extracellular domain of epidermal growth factor receptor in non-small cell lung cancer cells and monocyte. In vitro experiments, it