Cine DENSE MRI of Left Ventricular Dyssynchrony: Development and Initial Clinical Experience
Patel R, Epstein F, Kramer C, Hummel J, Ferguson J, Helm P, Spottiswoode B, Zhong X, Christopher J
University of Virginia
Cardiac resynchronization therapy (CRT) for patients with end stage heart failure improves hemodynamics, symptoms, exercise capacity, quality of life, and mortality. When current criteria are used to select patients for CRT, as many as 30% of patients are non-responders. The present study established the ability of cine DENSE and late gadolinium-enhanced MRI to detect mechanical dyssynchrony and scar, respectively, in heart failure patients. The ability to assess dyssynchrony and viability in a single exam may improve the ability to accurately select patients for CRT.