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Abstract #3602

In-situ observation of T2 and ADC changes in cartilage during collagen depletion

Hall L, Xing D, Tejos C, Crdenas-Blanco A
Herchel Smith Laboratory, University of Cambridge

This study reports the in-situ chemical and structural changes suffered by cartilage during enzymatic collagen depletion process, similar to the degradation process produced in osteoarthritic joints. Measuring T2 and the Apparent Diffusion Coefficient, it was found that each structural zone of the cartilage experimented different changes on the enzyme activity and the restriction to free water mobility during the degradation process.