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Abstract #3621

Quantification of Acute Peripheral Muscle Edema in Rats using MRI

Liachenko S, Dhamija S, Major T
Pfizer, Inc.

A clinically translatable MRI method for the detection of edema in the hind legs of spontaneously hypertensive rats is developed. The method is based on the MRI measurement of the proton transverse relaxation in skeletal muscle. The present study validates the MRI T2 measurements as a differentiating marker of peripheral muscle edema after acute infusion of the reference calcium channel blockers with a dose-response approach