Abstract #0054

Real-Time Cardiac Metabolism in a Pig Model of Cardiac Disease Using Hyperpolarized 13C MR

Angus Zoen Lau^1,2, Nilesh Ghugre², Albert P. Chen³, Wilfred W. Lam², Venkat Ramanan², Yuesong Yang², Graham A. Wright^1,2, Charles H. Cunningham^1,2

¹Dept. of Medical Biophysics, University of Toronto, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³GE Healthcare, Toronto, ON, Canada

Hyperpolarization of spins via DNP has been explored as a method to non-invasively study real-time metabolic processes in vivo. In this abstract, we investigate the use of hyperpolarized ¹³C MR to study real-time cardiac metabolism in a pig model of cardiac disease. A ¹³C-tuned transmit/receive surface coil was used to acquire cardiac-gated non-localized dynamic spectra following injection of a hyperpolarized [1-¹³C]-pyruvate solution. Pyruvate, lactate, and bicarbonate resonances were observed. Spatially encoded breath-held cardiac-gated CSIs were also obtained displaying the presence of pyruvate in the blood in the chambers of the heart.