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Abstract #0124

Spatiotemporal Correlation Between Alpha Modulation and BOLD Fluctuation in an Eyes-Open-Eyes-Closed Task

Lin Yang1, Zhongming Liu1, Cristina Rios1, Han Yuan1, Bin He1

1Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

The purpose of this study is to investigate the spatial and temporal relationship between the electrophysiological alpha rhythmic modulation and the BOLD fluctuation using an eyes-open-eyes-closed task. We reconstructed the spatiotemporal cortical source activity underlying the task-modulated EEG alpha rhythm. The resulting source activity was compared, in both space and time, with the BOLD signal recorded with the same task. The cortical regions generating alpha modulation were co-localized with the fMRI activations/deactivations within the occipital and parietal lobes, where the alpha modulation was found temporally negatively correlated with the BOLD fluctuation. The results may suggest a common neural origin that accounts for both alpha modulation and BOLD fluctuation due to transitions between two common resting conditions.