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Abstract #0129

Resting-State Connections in Prefrontal Cortex Indicate Cognitive Network Efficiency During Working Memoryτ

Jolyn Nicole Alexis D'Andrea1, Bradley G. Goodyear2

1Medical Science, University of Calgary, Calgary, Alberta, Canada; 2Radiology, University of Calgary, Calgary, Alberta, Canada

The dorsolateral prefrontal cortex (DLFPC) has been identified as critical for working memory, especially as task difficulty increases. The current study used fMRI to investigate resting-state connectivity between left and right DLPFC, and its relationship to recruitment of right DLFPC during a working memory task. Our results show that subjects exhibiting greater resting-state connectivity recruit DLPFC in the right hemisphere to a lesser degree during the performance of a working memory task, as the task becomes more complex. This suggests that subjects with greater resting-state connectivity may possess more efficient cognitive networks during working memory task performance.