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Abstract #0131

High Acceleration 3D Compressed Sensing Hyperpolarized 13C MRSI of a Transgenic Mouse Model of Liver Cancer

Simon Hu1,2, Asha Balakrishnan3, Michael Lustig4, Peder E Z Larson1, Robert Bok1, John Kurhanewicz1,2, Sarah J. Nelson1,2, John M. Pauly4, Andrei Goga3, Daniel B. Vigneron1,2

1Dept. of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; 2UCSF & UCB Joint Graduate Group in Bioengineering, San Francisco, CA, USA; 3Dept. of Medicine, Division of Hematology/Oncology, University of California, San Francisco, CA, USA; 4Dept. of Electrical Engineering, Stanford University, Stanford, CA, USA

Hyperpolarized technology has enabled rapid in vivo 13C spectroscopic imaging at high SNR. Acquisition time limitations due to rapid hyperpolarized signal loss make accelerated imaging methods, such as compressed sensing, extremely valuable. In this project, we developed a 3.4-fold accelerated compressed sensing 3D-MRSI sequence and acquired hyperpolarized spectra in a transgenic mouse model of liver cancer, observing elevated lactate and alanine in tumors at a 0.034 cm3 spatial resolution. We also developed a 7.5-fold accelerated sequence, which we validated in simulations and phantom experiments and applied to prostate cancer mice to achieve 4-fold resolution enhancement in approximately half the acquisition time.