He Zhu1,2, Ronald Ouwerkerk1, Richard A.E. Edden1,2, Michael Schr1,3, Peter B. Barker1,2
1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Maryland, MD, USA; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Maryland, MD, USA; 3Philips Healthcare, Cleveland, OH, USA
A dual band water and lipid suppression sequence was developed for in vivo multi-slice MRSI of the brain. This pre-pulse sequence consists of five frequency modulated pulses with variable delay times and flip angles. Both timing and flip angle parameters were optimized via simulations to suppress water and lipid signals simultaneously. Outer volume suppression pulses were integrated into the sequence to improve lipid suppression, particularly for lipid resonances outside of the dual-band suppression bandwidth. Experimental results at 3T show comparable water suppression performance to the longer VAPOR sequence, and excellent lipid suppression factors.