Abstract #0157

MEMRI Study of Neonatal Hypoxic-Ischemic Injury in the Late Stage

Iris Yuwen Zhou^1,2, Kevin C. Chan^1,2, Abby Y. Ding^1,2, Edward S. Hui^1,2, Ke Xia Cai^1,2, Ed X. Wu^1,2

¹Laboratory of Biomedical and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

In this study, in vivo MEMRI was employed to investigate the hypoxic-ischemic injury in the late phase. Mn2+ induced signal changes were examined using SPM coregistration and ROI analysis. T1WIs SI increase was detected in the perilesional region 24 hours after Mn2+ administration and it colocalized with the increase in glial cell density in GFAP staining, demonstrating the existence of reactive gliosis in the late phase after H-I injury.