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Abstract #0185

ZAPI Analysis of Z-Spectral Components in Acute Cerebral Ischemia

Johanna Nrvinen1, Kimmo T. Jokivarsi2, Penny Louise Hubbard3, Olli H. Grohn4, Risto A. Kauppinen5, Gareth A. Morris6

1Biomedical Imaging Unit, University of Kuopio, Kuopio, Finland; 2Dept. of Neurobiology, University of Kuopio, Kuopio, Finland; 3School of Medicine, University of Manchester, Manchester, UK; 4Dept. of Neurobiology, University of Kuopio, Kuopio, Finland; 5Dept. of Radiology, Dartmouth College, Hanover, NH, USA; 6School of Chemistry, University of Manchester, Manchester, UK

T2-selective Z-spectroscopy (ZAPI) was applied to acute cerebral ischemia. It was shown that the magnetization transfer (MT) component can be measured directly at and near water resonance using sinusoidally modulated low-power RF saturation. This information was used to improve the separation of MT from other components in a Z-spectrum. In this study, a small decrease in MT asymmetry in stroke was observed. In the ischemic striatum the amide signals at 3.5 ppm showed decreased amide-water exchange, while aliphatic signals at -3.5 ppm remained unchanged.