Abstract #0187

Z-Spectrum Asymmetry : From 3T to 7T

Olivier E. Mougin¹, Ron Coxon¹, Penny A. Gowland¹

¹Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, UK

Magnetization Transfer and related effects such as CEST are important sources of contrast in MRI. Studying MT in vivo at 7T is challenging due to the increase in longitudinal relaxation time and SAR limits. We used pulsed saturation with EPI readout a range of offset frequencies and on the approach to steady-state, providing data that can be used to measure MT parameters at 7T in a reasonable imaging time and to compare the z-spectrum at 7 and 3T. We have found considerably increased sensitivity to CEST at 7T.