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Abstract #0192

Unraveling Mouse Glioma Heterogeneity with DCE-T1 MRI and 1H-CSI Metabolome Pattern Perturbation

Rui Vasco Simes1,2, Maria Luisa Garca-Martn3, Teresa Delgado-Goi1,4, Silvia Lope-Piedrafita4,5, Carles Ars1,4

1Bioqumica i Biologia Molecular, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Barcelona, Spain; 2Bioqumica, Universidade de Coimbra, Coimbra, Portugal; 3Resonancia Magntica, Clnica Nuestra Seora del Rosario, Madrid, Spain; 4CIBER-BBN, Cerdanyola del Valls, Spain; 5Servei de Resonncia Magntica Nuclear, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Spain

In this work we have investigated the heterogeneity of GL261 mouse glioma (n=9) microenvironments in vivo by correlating the information obtained from dynamic contrast-enhanced T1 MRI (DCE-T1) with that from dynamic 1H-CSI during an acute hyperglycemic challenge. The distinct enhancement patterns given by DCE-T1 and 1H-CSI maps (MR-detectable glucose and lactate) suggest different vascularization/permeability and metabolism, respectively, in the different regions of each studied tumor. Other metabolome challenges should be tested to better understand GL261 in vivo sampled glioma regional heterogeneity.