Abstract #0201

Detection of Lung Metastases Using Hyperpolarized 3He MRI and Targeted Magnetic Nanoparticles Histologic Validation and Detection Limits

Rosa Tamara Branca¹, Zackary Cleveland², Boma Fubara², Challa Kumar³, Carola Leuschner⁴, Warren Sloan Warren⁵, Bastiaan Driehuys²

¹Center for molecular and biomolecular imaging, Duke University , Durham, NC, USA; ²Center for in vivo microscopy, Duke University, Durham, NC, USA; ³Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA, USA; ⁴William Hansel Cancer Prevention, Pennington Biomedical Research Center, Baton Rouge, LA, USA; ⁵Center for molecular and biomolecular imaging, Duke University, Durham, NC, USA

Breast and prostate metastases are detected in lungs using hyperpolarized helium MRI and targeted contrast agent. The method allows the detection of metastatic nodules smaller than 100 micrometers with high specificity and sensitivity and, more generally, can be used to detect and track any type of labeled cell in lungs