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Abstract #0201

Detection of Lung Metastases Using Hyperpolarized 3He MRI and Targeted Magnetic Nanoparticles Histologic Validation and Detection Limits

Rosa Tamara Branca1, Zackary Cleveland2, Boma Fubara2, Challa Kumar3, Carola Leuschner4, Warren Sloan Warren5, Bastiaan Driehuys2

1Center for molecular and biomolecular imaging, Duke University , Durham, NC, USA; 2Center for in vivo microscopy, Duke University, Durham, NC, USA; 3Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA, USA; 4William Hansel Cancer Prevention, Pennington Biomedical Research Center, Baton Rouge, LA, USA; 5Center for molecular and biomolecular imaging, Duke University, Durham, NC, USA

Breast and prostate metastases are detected in lungs using hyperpolarized helium MRI and targeted contrast agent. The method allows the detection of metastatic nodules smaller than 100 micrometers with high specificity and sensitivity and, more generally, can be used to detect and track any type of labeled cell in lungs