Thomas Christen1,2, Benjamin Lemasson1,3, Nicolas Pannetier1,2, Rgine Farion1,2, Christoph Segebarth1,2, Chantal Rmy1,2, Emmanuel L. Barbier1,2
1Inserm, U836, Grenoble, F-38043, France; 2Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, France; 3Oncodesign Biotechnology, Dijon, France
Recently, an in vivo MR approach quantitative BOLD was introduced to obtain blood volume fraction (BVf) and local blood oxygen saturation (lSO2) maps. The mesoscopic effect on T2* depends on both BVf and lSO2, but these two contributions are difficult to separate during data analysis. To improve the accuracy on the determination of lSO2, we introduce a different measurement scheme which combines a steady-state BVf measurement with standard B0 and T2 mapping. The proposed scheme was evaluated in healthy rats under an O2 challenge. Value of lSO2 are consistent with data from the litterature.
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