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Abstract #0231

Well-Defined, Multifunctional Nanostructures of a Paramagnetic Lipid and a Lipopeptide for Macrophage Imaging

Honorius M.H.F. Sanders1,2, Esad Vucic3, Nico A.J.M. Sommerdijk2, Enzo Terreno4, Francesca Arena4, Silvio Aime4, Klaas Nicolay1, Margaritta Dathe5, Zahi A. Fayad3, Willem J.M. Mulder3

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Brabant, Netherlands; 2Soft Matter Cryo-TEM Research Unit, Eindhoven University of Technology, Eindhoven, Brabant, Netherlands; 3Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, USA; 4Department of Chemistry IFM and Molecular Imaging Center, University of Torino, Torino, Italy; 5Leibniz Institute of Molecular Pharmacology, Berlin, Germany

In the field of targeted molecular imaging and therapy the pharmacokinetic profile as well as the tissue penetration potential of nanoparticulate formulations is of paramount importance. Hence, there is a great demand for nanostructures of which the final morphology and size can be judiciously controlled.