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Abstract #0287

Intravoxel Water Diffusion Heterogeneity of Human High-Grade Gliomas

Thomas Kwee1, Craig Galban1, Marko Ivancevic1,2, Pia Sundgren1, Christina Tsien3, Larry Junck4, Benjamin Hoff1, Charles Meyer1, Brian Ross1, Thomas Chenevert1

1Department of Radiology, University of Michigan, Ann Arbor, MI, USA; 2Philips Healthcare, Cleveland, OH, USA; 3Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA; 4Department of Neurology, University of Michigan, Ann Arbor, MI, USA

Diffusion-weighted signal decay of brain tissue is multi-exponential due to the presence of multiple intravoxel proton pools (IPPs) with different diffusion coefficients. This study investigated the intravoxel water diffusion heterogeneity (IDWH) of human high-grade gliomas (N=20), using the stretched-exponential model. IDWH was significantly higher in high-grade gliomas than in normal brain tissue, which potentially offers a new method for assessing tumor extent and evaluating therapeutic response. Correlation between tumor IDWH and overall tumor diffusion coefficient was strongly negative, suggesting that highly cellular tumors contain a lower number of distinct IPPs, while cystic/necrotic tumors contain a higher number of distinct IPPs.