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Abstract #0308

Young Investigator Award Finalist: Use of Cardiac Output to Improve Measurement of Tracer Input Function in Dynamic Contrast-Enhanced MRI

Jeff Lei Zhang1, Henry Rusinek1, Louisa Bokacheva1, Qun Chen1, Pippa Storey1, Vivian S. Lee1

1Radiology, New York University, New York, NY , USA

We present a new method for computing AIF from MR arterial signals using a constrained conversion that takes into account the subjects cardiac output. Monte Carlo simulations showed that by using the proposed method, the reproducibility of tumor perfusion parameters and renal function parameters was significantly improved (by at least a factor of three). Dynamic MR renography was repeated for volunteers on three separate days. We obtained similar results. The proposed method may be especially useful for analyzing repeated contrast-enhanced scans such as monitoring tumor therapy or ACE-inhibitor renography.