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Abstract #0335

Improving Spatial Localization in MR Spectroscopic Imaging with PSF-Choice

Lawrence Patrick Panych1,2, Joseph R. Roebuck3, Robert V. Mulkern2,4, Yi Tang1,2, Bruno Madore1,2, Nan-kuei Chen5

1Radiology, Brigham and Women's Hospital, Boston, MA, USA; 2Radiology, Harvard Medical School, Boston, MA, USA; 3Radiology, University of Texas Medical Branch, Galveston, TX, USA; 4Radiology, Children's Hospital, Boston, MA, USA; 5Brain Imaging and Analysis Center, Duke University, Durham, NC, USA

The purpose of this work was to improve the point-spread-function (PSF) of MR spectroscopic imaging (MRSI) to avoid corruption from neighboring voxels. PSF-Choice, a method that uses RF manipulation to shape the PSF in phase-encoding directions, was implemented. Evaluation of the method in extensive phantom experiments was conducted. In addition, an implementation of this method is reported for MRSI of the prostate, where it is demonstrated that, in 13 of 16 pilot prostate MRSI scans, intra-voxel spectral contamination from lipid is significantly reduced compared to a standard phase-encoding MRSI method.