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Abstract #0344

Whole-Brain Voxel-Wise Analysis of Myelin Water Volume Fraction in Multiple Sclerosis

Sean CL Deoni1

1Centre for Neuroimaging Sciences, London, UK

The ability to distinguish affected, but normal appearing, white matter tissue has significant clinical application to MS and other de-myelinating disorders. Currently, this may be accomplished using histogram analysis, but at the expense of spatial information. Here we demonstrate a patient-specific approach, involving the comparison of voxel-wise myelin volume fraction values, obtained using the mcDESPOT multi-component relaxometry technique, to a reference population-matched atlas. We demonstrate the ability to visualize areas of significantly reduced myelin fraction within tissue that appears normal on conventional T1 or T2 weighted scans.