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Abstract #0348

Neurochemical Profile of the Mouse Hypothalamus Using 1H MRS at 14.1T

Hongxia Lei1,2, Carole Poitry-Yamate1, Frederic Preitner3, Bernard Thorens3, Rolf Gruetter1,4

1Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland; 2Radiology, University of Lausanne , Lausanne, Vaud, Switzerland; 3Institute of Physiology, University of Lausanne , Lasuanne, Vaud, Switzerland; 4Radiology, University of Geneva, Geneva, Switzerland

MRS of hypothalamus in mice is very challenging due to its small volume and deep structure. In present study, we examine the feasibilities of 1H MRS of the hypothalamus in GLUT8 knockout mice at 14.1T. The quality spectra resulted in nearly 20 metabolites, so called the neurochemical profile of the mouse hypothalamus.