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Abstract #0352

In Situ 3D MR Metabolic Imaging of Microwave-Irradiated Rodent Brain: A New Tool for Metabolomics Research

Robin A. de Graaf1, Golam MI Chowdhury1, Peter B. Brown1, Douglas L. Rothman1, Kevin L. Behar1

1MRRC, Yale University, New Haven, CT, USA

High-resolution and high-sensitivity MR imaging and spectroscopy on microwave-irradiated rat brain is demonstrated. Structural integrity and metabolic stability are confirmed for at least 12 hours through the use of DTI and T2-weighted MRI and 1H MRS. 1H MR spectra of microwave-irradiated rat brain are indistinguishable from in vivo 1H MR spectra. When combined with in vivo infusion of 13C-labeled compounds, the in situ 1H MRSI data allows the detection of metabolic fluxes at high spatial resolution.