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Abstract #0430

Prenatal Cocaine Exposure Alters Ventromedial Prefrontal Activity Associated with Emotion Regulation

Zhihao Li1, Priya Santhanam1, Claire D. Coles2, Mary Ellen Lynch2, Stephan Hamann3, Xiaoping Hu1

1Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, USA; 2Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA; 3Psychology, Emory University, Atlanta, GA, USA

Prenatal cocaine exposure (PCE) is associated with arousal dysregulation but the neurobiological bases have not been well investigated yet. The present fMRI data showed that PCE subjects could not increase their ventromedial prefrontal activation in excerting emotional suppression, which complemented previous findings about altered amygdala emotional responses in PCE subjects.