Kevin D. Harkins1, Jean-Phillipe Galons2, Joe L. Divijak1, Theodore P. Trouard1
1Biomedical Engineering, University of Arizona, Tucson, AZ, USA; 2Radiology, University of Arizona, Tucson, AZ, USA
The apparent diffusion coefficient is a measure of water diffusion in tissue, and is sensitive to cellular properties and tissue integrity. In this work, we present estimates of the intrinsic intracellular diffusivity derived from hollow-fiber bioreactor cell culture measurements using oscillating gradient diffusion measurements at very short diffusion times. The ADC of intracellular approaches 2.0 to 2.4 mm2 /ms as the diffusion time approaches 0 ms.